NTUIMCB

近年研究主題

1. 葉綠體galactolipid生合成與代謝

2. 微藻中多不飽和脂肪酸的生合成調控

研究室簡介: 葉綠體脂質實驗室

半乳糖脂(galactolipids)是植物plastids上一類特殊的脂質，葉綠體中有80%的脂質是由單半乳糖脂(MGDG)及雙半乳糖脂(DGDG)所構成。在植物葉綠體及藍綠菌中都富含半乳糖脂，但是不行光合作用的生物中缺乏半乳糖脂的存在，這顯示出半乳糖脂對於光合作用有特殊的功能。我們的研究顯示，MGDG/DGDG ratio上升會促使植物生成大量植物賀爾蒙JA，藉以維持植物體內MGDG/DGDG的恆定性。因此，半乳糖脂除了維持光合作用的功能以外，它也是合成植物賀爾蒙JA的前驅物。當植物處於缺磷的逆境下，半乳糖脂更可以從葉綠體運送到其他胞器來替代磷脂質的部分功能。我們的近期研究著重在植物中半乳糖脂的生合成及代謝路徑，希望了解MGDG/DGDG的恆定性如何誘導JA的生合成。

      不同於阿拉伯芥中半乳糖脂的脂肪酸組成以16碳及18碳為主，特定微藻的MGDG 和 DGDG具有更高碳數(20碳及22碳)的脂肪酸鏈，我們的長期目標是將我們對半乳糖脂質和脂肪酶的研究擴展到藻類，探討微藻中omega-3 (20:5, EPA或22:6, DHA)的生合成調控機制。

學術著作

Publications

1. Chun-Wei Yu, Van C. Nguyen, Niña Alyssa M. Barroga, Yuki Nakamura, and Hsou-min Li* (2024, Oct). Plastid LPAT1 is an integral inner envelope membrane protein with the acyltransferase domain located in the stroma. Plant Cell    Reports, 43: 257.

2. Sujuan Gao, Xueqin Zeng, Jianhao Wang, Yingchao Xu, Chun-Wei Yu, Yishui Huang, Feng Wang, Keqiang Wu,* and Songguang Yang* (2021, Nov). Arabidopsis SUMO E3 Ligase SIZ1 Interacts with HDA6 and Negatively Regulates HDA6 Function during Flowering. Cells, 10: 3001. 

3. Chun-Wei Yu, Yang-Tsung Lin, and Hsou-min Li* (2020, Jun). Increased ratio of galactolipids MGDG:DGDG induces jasmonic acid overproduction and changes chloroplast shape. New Phytologist, 228: 1327-1335. 

4. Hsou-min Li*, Chun-Wei Yu (2018, May). Chloroplast Galactolipids: The Link Between Photosynthesis, Chloroplast Shape, Jasmonates, Phosphate Starvation and Freezing Tolerance. Plant and Cell Physiology, 59: 1128-1134. 

5. Chun-Wei Yu, Ready Tai, Shen-Chi Wang, Ping Yang, Ming Luo, Songguang Yang, Kai Cheng, Wen-Chun Wang, Yi-Sheng Cheng, and Keqiang Wu* (2017, Aug). HISTONE DEACETYLASE6 Acts in Concert with Histone Methyltransferases SUVH4, SUVH5, and SUVH6 to Regulate Transposon Silencing. Plant Cell, 29: 1970-1983. 

6. Chun-Wei Yu, Kao-Yuan Chang and Keqiang Wu* (2016, Apr). Genome-Wide Analysis of Gene Regulatory Networks of the FVE-HDA6-FLD Complex in Arabidopsis. Frontiers in Plant Science, 7: 555.

7. Ming Luo^#, Ready Tai^#, Chun-Wei Yu^#, Songguang Yang, Chia-Yang Chen, Wen-Dar Lin, Wolfgang Schmidt and Keqiang Wu* (2015, Jun). Regulation of flowering time by the histone deacetylase HDA5 in Arabidopsis. The Plant Journal, 82:925-936. # equal contribution.

8. Chia-Chi Hsu, Pei-Shan Wu, Tien-Chih Chen, Chun-Wei Yu, Wen-Chieh Tsai, Keqiang Wu, Wen-Luan Wu, Wen-Huei Chen, Hong-Hwa Chen* (2014, Dec). Histone Acetylation Accompanied with Promoter Sequences Displaying Differential Expression Profiles of B-Class MADS-Box Genes for Phalaenopsis Floral Morphogenesis. PLoS ONE, 9: e106033. 

9. Prashant Singh, Shweta Yekondi, Po-Wen Chen, Chia-Hong Tsai, Chun-Wei Yu, Keqiang Wu, Laurent Zimmerli* (2014, Jun). Environmental History Modulates Arabidopsis Pattern-Triggered Immunity in a HISTONE       ACETYLTRANSFERASE1-Dependent Manner. Plant Cell, 26: 2676-2688. 

10. Xuncheng Liua, Songguang Yanga, Minglei Zhaoa, Ming Luo, Chun-Wei Yu, Chia-Yang Chen, Ready Tai, and Keqiang Wu* (2014, May). Transcriptional Repression by Histone Deacetylases in Plants. Molecular Plant, 7: 764-772. 

11. Yi Zhou, Bin Tan, Ming Luo, Yin Li, Chen Liu, Chen Chen, Chun-Wei Yu, Songguang Yang, Shuai Dong, Jiuxiao Ruan, Liangbin Yuan, Zhou Zhang, Linmao Zhao, Chenlong Li, Huhui Chen, Yuhai Cui, Keqiang Wu and Shangzhi Huang* (2013, Jan). HISTONE DEACETYLASE19 Interacts with HSL1 and Participates in the Repression of Seed Maturation Genes in Arabidopsis Seedlings. Plant Cell, 25: 134-148. 

12. Ming Luo^#, Chun-Wei Yu^#, Fang-Fang Chen, Linmao Zhao, Gang Tian, Xuncheng Liu, Yuhai Cui, Jun-Yi Yang, Keqiang Wu* (2012, Dec). Histone Deacetylase HDA6 Is Functionally Associated with AS1 in Repression of KNOX Genes in Arabidopsis. PLOS genetics, 8: e1003114. # equal contribution.

13. Xuncheng Liu, Chun-Wei Yu, Jun Duan, Ming Luo, Koching Wang, Gang Tian, Yuhai Cui and Keqiang Wu* (2012, Jan). HDA6 Directly Interacts with DNA Methyltransferase MET1 and Maintains Transposable Element Silencing in          Arabidopsis. Plant Physiology, 158: 119-129. 

14. Chun-Wei Yu, Xuncheng Liu, Ming Luo, Chiayang Chen, Xiaodong Lin, Gang Tian, Qing Lu, Yuhai Cui, and Keqiang Wu* (2011, May). HISTONE DEACETYLASE6 Interacts with FLOWERING LOCUS D and Regulates Flowering in Arabidopsis. Plant Physiology, 156: 173-184. 

15. Malona V Alinsug, Chun-Wei Yu and Keqiang Wu* (2009, Mar). Phylogenetic analysis, subcellular localization, and expression patterns of RPD3/HDA1 family histone deacetylases in plants. BMC Plant Biology, 9: 37. 

16. Keqiang Wu*, Lin Zhang, Changhe Zhou, Chun-Wei Yu and Vijaya Chaikam (2008, Jan). HDA6 is required for jasmonate response, senescence and flowering in Arabidopsis. Journal of Experimental Botany, 59: 225-234. 

開設課程